Nurture Integrative Health

After a brain injury, your brain can feel like it is on fire. Leading to constant brain fog, headaches, intolerance of light or noise, inability to focus or concentrate, sleep disturbances, and much more. The inflammatory process occurs with the neurometabolic cascade when the microglia cells are activated. The microglia, the cells that surround and nourish neurons, are immune cells that scavenge for plaques, damaged or unnecessary neurons and synapses, and infectious processes. Basically, they are the clean-up crew. When the microglia are over-activated their morphology or shape changes and they are no longer able to effectively clean-up debris. 

The long-term activation of the microglia is called glial priming. Glial priming is one of the most overlooked causes of long-term symptoms. 

After a traumatic brain injury, the inflammatory cytokines and genes are upregulated. This upregulation has been associated with damage to the substantia nigra that produces dopamine. This explains both the mood changes and Parkinsons-like symptoms. An Oxford study theorizes that the increase in glutamate release and activation of immune receptors from oxidative stress leading to immunotoxicity. For a refresher on Oxidative Stress, visit my post here

The glial priming can affect cognition, behavioral changes, brain fog, headaches, dizziness, and a slew of other symptoms. It is important to put the fire out quickly. 

Some approaches to extinguishing the fire include: 

  1. Fish Oil 

  2. Curcumin or Turmeric 

  3. Antioxidant support like resveratrol or NAC 

  4. Reducing foods that are known to cause inflammation like gluten or dairy 

  5. Reducing lifestyle choices that can lead to increase inflammation including smoking or alcohol consumption 

PMID: 25232881, 25599342, 27724914

Our Newsletter

Sign up to receive our latest news and health tips!

You may unsubscribe at any time per our Privacy Policy.